Complete the game without opening the Item Box more than 3 times.
Complete the game on Normal.
Complete the game on Madhouse.
Obtain all of the Antique Coins in Madhouse difficulty.
Complete the game within 4 hours.
Complete the game using only 3 First Aid Meds or less.
Get ending 1.
Avoid Jack's scissor attack by crouching.
Complete the game on Easy.
Get ending 2.
Destroy all Mr. Everywhere statuettes.
Read all of the files in a single playthrough.
Escape from the ship.
Obtain all of the Antique Coins in Easy or Normal difficulty.
Kill an enemy by attaching a Remote Bomb to them and detonating it.
Watch all the videotapes in a single playthrough.
Escape from the Baker family home.
Complete the "Happy Birthday" videotape within 5 minutes.
Create all items that contain Chem Fluid and Strong Chem Fluid.
Uncover the secret in the old house.
Shoot and knock back Marguerite while she's leaping at you.
Fight off Marguerite while she wanders the old house to make her run away.
Clear insects off a door using a knife.
Take down two or more enemies with one shot.
Increase your item slots.
Escape to the yard.
Use psychostimulants.
Finish off an enemy with the knife.
Complete the "Mia" videotape without being spotted by Marguerite.
Put an unrelated object on a shadow plinth.
Destroy a Mr. Everywhere statuette.
Block an enemy attack by guarding.
Escape from the guest house.
Use a lock pick to open something.
Close an open door by yourself.
Obtain something by closely examining an item.
Travel to Louisiana.
Complete Nightmare.
Complete Night Terror.
Complete Bedroom.
Find all the dead rats in Bedroom in a single play.
Complete Ethan Must Die.
Complete 21.
Complete Survival mode in 21.
Complete Survival+ mode in 21.
Get the bad ending in Daughters.
Get the true ending in Daughters.
Clear a stage with a 10 minute time bonus or higher in Jack's 55th Birthday.
Feed Jack every type of food and drink in Jack's 55th Birthday.
Get an S Rank or higher on all stages in Jack's 55th Birthday.
Complete End of Zoe on Easy or Normal.
Complete End of Zoe on Joe Must Die.
Complete End of Zoe on Normal or Joe Must Die using no weapons.
Complete an Extreme Challenge in End of Zoe.
Perform a 4-hit combo with your bare fists in End of Zoe.
Stealth kill 5 enemies in End of Zoe.
Complete Not a Hero on Easy or Normal difficulty.
Complete Not a Hero on Professional difficulty.
